Hereditary CRC syndromes encompass (i) non-polyposis hereditary syndromes including LS, Lynch-like syndrome, familial CRC type X, (ii) polyposis syndromes including familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and the serrated polyposis syndrome (SPS); and (iii) hamartomatous syndromes including Peutz-Jeghers syndrome, juvenile polyposis syndrome, and PTEN-hamartomatous tumor syndrome [17,21]. This evidence concerns the gene PTEN and mutyh-associated polyposis.