ERBB2 and breast cancer: However, unlike the studies on the prognostic value of the NLR, heterogeneity was greater in this meta-analysis, since some studies found a better response to ICT in patients with elevated NLR, such as a recent large study in HER-2 negative breast cancer patients (n = 1097) that also showed that a high NLR was an independent predictor of complete pathologic response after neoadjuvant chemotherapy [27].