Oncogenic TRIMs, like TRIM11, TRIM21, TRIM23, TRIM24, TRIM25, TRIM28, TRIM29, TRIM31, TRIM32, TRIM39, TRIM59, and TRIM66, directly or indirectly inhibit the activity of tumor suppressor protein p53, whereas other TRIMs, such as TRIM3, TRIM13, TRIM19, and TRIM67, can exercise their anti-cancer capacity by inducing the activity of p53 [27]. The gene discussed is TP53; the disease is cancer.