VEGFA and breast cancer: Furthermore, melatonin at 1 mM concentration can inhibit the angiogenesis in MCF-7 breast cancer cells; Alvarez-Garcı’a et al. suggest that melatonin may play a role in the paracrine interactions between malignant epithelial cells and proximal endothelial cells through a downregulatory action on VEGF expression in human breast cancer cells, which decrease the levels of VEGF around endothelial cells [67,68].