Chronic training increased the mRNA level of PGC-1α of SAT by 1.2-fold and 1.6-fold in the control group and the pre-diabetes group, respectively, whereas no significant changes neither in the brown-fat-selective gene Prdm16 or other known browning genes TBX1, TMEM26, and CD137 for both groups. This evidence concerns the gene PRDM16 and diabetes mellitus.