VHL and neoplasm: However, it is well known that some genes including APC, BNC1, CDH1, ECAD, GSTP1, KTN19, IGFBP1, IGFBP3, MGMT, PTGS2, p14ARF, p16/CDKN2a, p16INK4a, RASSF1A, RARB2, SRFP, TIMP3, UCHL1, and VHL are silenced in RCC by DNA methylation and this could be useful for the diagnosis of RCC in tumor tissue, serum, or urine samples, both in the familiar and sporadic forms [12,59,60,61,62,63,64,65,66].