Inactivating mutations described for SETD2 (H3K36 methyltransferase), KDM5C (H3K4 demethylase), KMD6A (H3K27 demethylase), MLL2 (H3K4 methyltransferase), Polybromo 1 (PBRM1), BRCA1 Associated Protein-1 (BAP1) remain among the most interesting epigenetic mechanisms for ccRCC progression. This evidence concerns the gene BAP1 and nonpapillary renal cell carcinoma.