In fact, data from The Cancer Genome Atlas (TCGA) revealed that of all RCC subtypes, oncocytoma and chRCC are the most similar but, what is even more interesting, a signature of 30 hypermethylated genes distinguishes oncocytoma from chRCC [48,71] involved, among others, in Wnt, MAPK, and TGFβ signaling [48]. The gene discussed is TGFB1; the disease is renal cell carcinoma.