In order to investigate the association of miRNA with PCa aggressiveness, we compared miRNA expression levels in PCa patients with different WHO 2016/ISUP grade groups, Iow/high WHO 2016/ISUP grade group (≤2 vs ≥3), low/high biopsy GS group (=6 vs ≥7), and low/high PSA levels (≤10 vs >10 μg/L). This evidence concerns the gene KLK3 and posterior cortical atrophy.