They found that IL-6 induces cisplatin resistance in tumor cells by upregulation of anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia 1 (Mcl-1) and DNA repair-associated molecules ATM kinase, checkpoint kinase 1 (CHK1), tumor protein 73 (TP73), p53, and ERCC1 [32]. This evidence concerns the gene PROS1 and neoplasm.