He was considered to have an advanced stage HCC (BCLC C, CPS A, ECOG PS 1) and he was started on sorafenib 400 mg/day, but one month later he was switched to regorafenib 160 mg/day because CT showed thrombosis progression and AFP levels up to 46,255 ng/mL. This evidence concerns the gene AFP and hepatocellular carcinoma.