The second case was a female, 24 years old with an etiology of thrombophlebitis accentuated by the presence of PAI-1 gene polymorphism-homozygous phenotype 4G/4G and oral contraceptives use, hospitalized with meningeal symptoms, left hemiparesis, generalized seizures and psychomotor agitation. The gene discussed is SERPINE1; the disease is Thrombophlebitis.