CD40LG and monoclonal gammopathy: The combination of both variables, immunoparesis and lymphoplasmacytic infiltration ≥20%, allowed us to identify a group of patients who lacked both biomarkers and had a particularly good prognosis, with cumulative incidences of progression of 3% and 6% at 10 and 20 years from diagnosis of asymptomatic IgM monoclonal gammopathy, showing a very slow and indolent behavior.