A major predictor of survival for PanNET is tumor grade based on the Ki67 proliferation index, which separates PanNETs into G1 (Ki67 < 3%), G2 (Ki67 ≥ 3%–≤ 20%) and G3 (Ki67 > 20%) neoplasms [11]. The gene discussed is MKI67; the disease is neoplasm.