JWH-105 inhibited EMT in non-small cell lung cancer cells (NSCLC) by suppressing ERK and STAT-3 activation and EGFR signaling; in addition, JWH-105 reduced invasiveness of A549 cells when co-cultured with M2 macrophages, by downregulating the expression of FAK, VCAM1, and MMP-2. This evidence concerns the gene STAT3 and non-small cell lung carcinoma.