CRC cells also produce PRL-3 and tumor necrosis factor-α (TNF-α) that increase the expression of intermediate-conductance Ca2+-activated potassium (KCNN4) channels in TAMs [23]; KCNN4 induce the secretion of IL-6 and IL-8 by TAMs and improve CRC cell invasiveness [24]. The gene discussed is IL6; the disease is colorectal carcinoma.