In humans, it has been shown that PRP enhances migration and proliferation of endometrial cells [29], promotes neo-angiogenesis in the endometrium of infertile women [30], and upregulates genes involved in implantation (e.g., prostaglandin-endoperoxide synthase 2 [COX2], tumor protein p53 [TP53], estrogen receptors [ER-α and ER-ß] and progesterone receptor) [31]. The gene discussed is ESR1; the disease is Infertility.