NPPB and heart failure: Nordin et al. proposed three stages of cardiac involvement in FD: (1) storage stage with normal or low native T1 times without LVH; (2) inflammation and myocyte hypertrophy stage with low native T1 times, inflammation, LGE, chronic troponin elevation, with LVH in males and without LVH in females; and (3) fibrosis and impairment stage with pseudonormalization of native T1 times, extensive LGE, LVH, troponin and NT-proBNP elevation, LV dysfunction, and heart failure [75].