BBC3 and Miyoshi myopathy: Decreased MM cell growth induced by inhibition of miR-221/222 plus melphalan is associated with upregulation of the pro-apoptotic BBC3/ Bcl-2-binding component 3 (PUMA) protein, a miR-221/222 target, as well as with modulation of the drug influx–efflux L-type amino acid transporter 1 (LAT1 or SLC7A5) and the ABC transporter ABCC1/ multidrug resistance-associated protein 1 (MRP1) [118].