FN1 and Miyoshi myopathy: Cell-adhesion mediated drug resistance (CAM-DR) to melphalan is induced in MM cell lines and in patient primary cells through adhesion to fibronectin or bone marrow stromal cells (BMSCs), which is mediated by very late antigen-4 (VLA4) integrin (α4β1) and VLA-5 (α5β1) [122].