The drugs involved in specific therapy for cardiovascular surgery patients (such as coumarins, heparin, salicylates, nitrosalicylates, diuretics, ACE inhibitors, calcium antagonists, β-blockers, nitroglycerin, and so on), the metabolic disorder implying overproduction of free radicals, and the anomalous nutrient intake poor in natural antioxidants will all affect the TAC value and its speciation. This evidence concerns the gene ACE and Other metabolic disease.