ACE and metabolic disease: The drugs involved in specific therapy for cardiovascular surgery patients (such as coumarins, heparin, salicylates, nitrosalicylates, diuretics, ACE inhibitors, calcium antagonists, β-blockers, nitroglycerin, and so on), the metabolic disorder implying overproduction of free radicals, and the anomalous nutrient intake poor in natural antioxidants will all affect the TAC value and its speciation.