In addition to previously known risk factors for HCC incidence, including male sex (aHR 2.78), old age (aHR 1.08), cirrhosis (aHR 2.95), and alcohol (aHR 2.10), ALT non-normalization within 1 year had a strong aHR of 2.64 for HCC development. The gene discussed is GPT; the disease is hepatocellular carcinoma.