UCP1 and diabetic cardiomyopathy: Considering the previous studies, the upregulation of Ucp-1 expression in BAT and WAT browning of DIO mice via MHW intake is considered to induce protective effects against diabetic cardiomyopathy via the upregulation of Ucp-1 expression in BAT, thereby probably decreasing ROS generation and activating eNOS in BAT (Figure 4).