Transcripts and protein expression from tumor tissue of mice inoculated with HepG2 cells overexpressing SerpinB3 not only confirmed the overexpression of SerpinB3 and the lower values of p66shc but also showed barely detectable levels of β-catenin, at variance with controls, where its expression was significantly higher (Figure 8A–C and Supplementary Figure S5). This evidence concerns the gene SERPINB3 and neoplasm.