Our results showed significantly lower levels of CARD8 in AOSD patients (median, 10524.6 pg/mL, inter-quartile range (IQR): 5644.4-21,173.6 pg/mL) compared with the controls (median, 13,964.1 pg/mL, IQR: 11,219.6-20,051.3 pg/mL, p = 0.005), while higher levels of IL-1β, and IL-18 in AOSD patients (median, 2.1 pg/mL, IQR: 1.0–4.8 pg/mL; and 1495.8 pg/mL, IQR: 466.7–10,970.7 pg/mL; respectively) compared with the controls (median, 1.0 pg/mL, IQR: 0–1.7 pg/mL; and 141.4 pg/mL, IQR: 103.1–181.9 pg/mL; respectively, both p < 0.001). The gene discussed is IL1B; the disease is adult-onset Still disease.