MDM2 and neoplasm: There are also several genes that carry mutations in only one or two of the nine regions within the same tumor, such as ARID2, BAD, BCL2, BRAF, CBL, CDKN2B, FBXW7, KMT2D, MDM2, MET, MYC, PIK3CA, PTEN, SF3B1, SOX2, TERT and TP53 (Figure 3D).