We found strong positive correlations for tTau and p181-Tau levels in NEVs and cortical and hippocampal tissues, which were driven by 3xTg-AD mice (Figure 2j–m; tTau: r = 0.3927 with p = 0.0092 for NEVs vs. cortex; p181-Tau: r = 0.6718 with p < 0.0001 for NEVs vs. Ctx and r = 0.5769 with p < 0.0001 for NEVs vs. Hp). This evidence concerns the gene HP and Alzheimer disease.