HP and Alzheimer disease: Luminex Multiplex results in Figure 3a,b show that 5xFAD mice (~12-month-old) had higher Aβ42 levels in the Ctx, Hp and NEVs compared to 2xTg-AD (~8 month-old), 3xTg-AD (~9 month-old), and WT mice (~9 month-old) (one-way ANOVA; 5xFAD Ctx: p = 0.004 vs. WT mice and p = 0.0104 vs. 3xTg-AD mice; 5xFAD Hp: p < 0.0001 vs. WT and 3xTg-AD mice, and p = 0.0132 vs. 2xTg-AD mice; 5xFAD NEVs: p = 0.0023 vs. WT mice, p = 0.0021 vs. 2xTg-AD mice and p < 0.0001 vs. 3xTg-AD mice).