The 2xTg-AD amyloidosis mouse model expresses the human amyloid precursor protein (APP) KM670/671NL (Swedish; APPswe) and presenilin-1 (PSEN1) ΔE9 mutations in the central nervous system (CNS) under the control of the mouse prion protein promoter [28], resulting in pathological APP processing and accumulation of Aβ plaques. Here, PSEN1 is linked to Alzheimer disease.