MAPT and Alzheimer disease: Among biomarkers of Tau pathology, we focused on p181-Tau given that it is a well-established marker of neurofibrillary tangles (NFTs) in 3xTg-AD mice [25,34] and AD brains [39], a CSF and plasma biomarker used to support AD diagnosis [40,41,42,43], and the strongest predictor of AD in previous NEV studies [12,17,19].