A study was performed with a customized NGS panel (called SiRe) including six genes [EGFR, KRAS, NRAS (NRAS Proto-Oncogene, GTPase), BRAF, KIT Proto-Oncogene Receptor Tyrosine Kinase (KIT)), Platelet-Derived Growth Factor Receptor Alpha (PDGFRA)] for 194 patients with advanced adenocarcinomas [46]. This evidence concerns the gene KRAS and adenocarcinoma.