p38α MAPK is involved in the induction of the expression of several inflammatory cytokines [70] such as TNF-α, IL-1, and IL-6 and other mediators of inflammation such as cyclooxygenase 2 (COX2), contributing to the development and progression of gliomas, breast cancer, head and neck squamous cell carcinoma, skin cancer or colorectal cancer (CRC) [71,72,73,74]. The gene discussed is PTGS2; the disease is central nervous system cancer.