PTGS2 and cancer: In particular, TTP promotes mRNAs degradation, action inhibited by p38 and/or MK2 [78,79,80], for example, to increase TNF-α mRNA stability [81,82] and other mRNAs involved in inflammation and cancer growth such as COX-2 (Cyclooxygenase-2), VEGF (Vascular endothelial growth factor), and IL-10 [3].