The AUC of using mpMRI and SelectMDx test together was 0.72 (95% CI 0.67–0.77) to detect PCa and 0.73 (95% CI 0.67–0.80) for csPCa, compared to 0.70 (95% CI 0.65–0.75) and 0.72 (95% CI 0.65–0.78), respectively, for the association mpMRI and PSA, and 0.67 (95% CI 0.62–0.71) and 0.68 (95% CI 0.62–0.75), respectively, for the association mpMRI and PSAD (Figure S2a,b). This evidence concerns the gene KLK3 and posterior cortical atrophy.