Further studies have reported genetic linkage of the NPSR1 locus on human Chr7 with inflammatory or allergic disorders, including asthma, airway hyper-responsiveness, atopic dermatitis, inflammatory bowel syndrome, and rheumatoid arthritis [83,84,85,86,87,88,89,90,91,92,93,94], although some studies failed to replicate such associations [95,96,97,98]. The gene discussed is NPSR1; the disease is asthma.