TNFRSF11A and precursor B-cell acute lymphoblastic leukemia: In detail, Rajakumar and colleagues showed that the transplant of primary B-ALL cells in NSG recipient mice induced trabecular bone destruction, associated with increased multinucleated osteoclasts and that the receptor activator of NF-kB (RANK)/RANK ligand (RANKL) axis was a key mediator of these effects.