BMP4 and acute lymphoblastic leukemia: Interestingly, it has been published that ALL-MSCs isolated from BM aspirates at disease diagnosis and early phases of treatment (day+15) can produce higher BMP4 levels compared to HD-MSCs or ALL-MSCs isolated from out of therapy patients and that its production could be further induced by MSC co-culture with the t(12;21) B-ALL cell line REH [60].