CX3CR1 and acute lymphoblastic leukemia: Interestingly, we also demonstrated for the first time a significant increase in CX3CL1 in the BM plasma of pediatric patients at B-ALL diagnosis compared to age-matched controls, suggesting that the CX3CL1/CX3CR1 could represent a novel chemokine axis crucial for the recruitment of NC monocytes to the leukemic BM niche [70].