Interestingly, we also demonstrated for the first time a significant increase in CX3CL1 in the BM plasma of pediatric patients at B-ALL diagnosis compared to age-matched controls, suggesting that the CX3CL1/CX3CR1 could represent a novel chemokine axis crucial for the recruitment of NC monocytes to the leukemic BM niche [70]. The gene discussed is CX3CL1; the disease is acute lymphoblastic leukemia.