Preclinical evidence [62,66,67] suggested a potential neuroprotective effect of estrogens on dopaminergic neurons and in preventing brain damage through anti-inflammatory, anti-oxidative, and anti-apoptotic mechanisms [68,69], along with possible inhibitory effects on the formation and stabilization of α-synuclein fibrils, a key pathological feature of PD. The gene discussed is SNCA; the disease is Parkinson disease.