DRD2 and acute myeloid leukemia: In a phase 1 clinical trial evaluating the use of thioridazine in combination with cytarabine in AML patients, the extent of leukemic blast reduction after thioridazine treatment was associated with expression of DRD2 on leukemic cells [70], suggesting that thioridazine’s ability to inhibit CSC function is downstream of DRD2 antagonism.