The VSV has been modified to express two extra genes: IFN-beta and TYRP1. IFN-β may protect normal healthy cells from becoming infected with the virus and improve the antitumor efficacy due to its intrinsic antiproliferative effects and tyrosinase-related protein 1 (TYRP1) is a tumor-associated antigen expressed both in CM and UM. This evidence concerns the gene TYRP1 and neoplasm.