However, a study considering 35 archival formalin-fixed, paraffin-embedded M-UM specimens described a tumor microenvironment in which M2-macrophages were the dominant subtype, CD4+ TILs were perivascular, and CD8+ lymphocytes were mainly peritumoral [59], suggesting that immune cells cannot invade the tumor to attack tumor cells. Here, CD8A is linked to neoplasm.