IKZF1 and Miyoshi myopathy: IMiDs (such as thalidomide and lenalidomide) function by altering the target specificity of CUL4A-DDB1-Cereblon E3 ubiquitin ligase, which in MM, leads to the degradation of two key PC transcription factors, Ikaros (IKZF1) and Aiolos (IKZF3) [20,21].