Besides increased VEGF expression, overactivation of the PI3K/mTOR pathway has also been associated with increased expression of other immunosuppressive cytokines and chemokines, such as CCL20, CXCL1, IL-6, IL-23, and IL-10, and increased expression of PD-L1 on the surface of tumor cells [58,59]. The gene discussed is CD274; the disease is neoplasm.