Polymorphisms in the GSTP1 (rs1695), ITGA4 (rs1143676), NQO1 (rs1800566), AKT1 (rs2498804), and GP6 (rs2304166) genes have shown an association with response to natalizumab, ZMIZ1 (rs1782645) to fingolimod and dimethyl fumarate, ADA (rs244072) to cladribine, and NOX3 (rs6919626) to dimethyl fumarate in patients with MS. This evidence concerns the gene ITGA4 and myeloid sarcoma.