GJA1 and ischemia: The importance of Cx43 in ventricular conduction and arrhythmogenesis has been strengthened by the finding that an enhancement in gap junctional coupling by antiarrhythmic peptides, including AAP10 and rotigaptide, two AAP derivatives, increased ventricular conduction under baseline conditions and prevented conduction slowing during ischemia in isolated rabbit and guinea pig hearts [400,401].