AKT1 and ovarian carcinoma: Novel studies consider blocking several pathways, for example, the combination of the tyrosine kinase inhibitor sunitinib with phosphoinositide 3-kinase/protein kinase B/Akt/mechanistic Target of Rapamycin (PI3K/AKT/mTOR) inhibitor, everolimus, and proto-oncogene tyrosine-protein kinase SRC inhibitor, dasatinib, showed synergistic antitumor activity in an ovarian cancer model [67].