Transcriptome and proteomic analysis of fibrosarcoma cells in which nuclear translocation of Sdc1 occurs has revealed the activation of the TGF-β pathway and altered expression of early growth response 1 (EGR-1), never-in-mitosis gene a-related kinase 11 (NEK11), and dedicator of cytokinesis 8 (DOCK8) genes that are coupled with growth and cell-cycle regulation. The gene discussed is SDC1; the disease is fibrosarcoma.