Nuclear translocation of Sdc-1 hampers the proliferation of fibrosarcoma cells by interfering with the cell cycle; however, proteolytic generation of a C-terminal fragment of Sdc-1 by ADAM 17 inhibits lung tumour cell migration but promotes lung epithelial tumour cell migration and metastasis [171] Shed Sdc-1 mediates tumour–host cell communication in myeloma cells by shuttling growth factors to the nucleus and by altering histone acetylation [9]. This evidence concerns the gene SDC1 and plasma cell myeloma.