YBEY and breast cancer: While the power and, thus, interpretation of our RNA-seq analysis is limited due to the small sample size, this is the first study to indicate a potential function of human YBEY. Transient k.d. using siRNAs greater than 23 bp in length has been reported to induce interferon signaling [21]; however, the siRNAs used in this study were less than 20 bp, which should minimize any innate immune signaling in our breast cancer cell lines.