While the power and, thus, interpretation of our RNA-seq analysis is limited due to the small sample size, this is the first study to indicate a potential function of human YBEY. Transient k.d. using siRNAs greater than 23 bp in length has been reported to induce interferon signaling [21]; however, the siRNAs used in this study were less than 20 bp, which should minimize any innate immune signaling in our breast cancer cell lines. This evidence concerns the gene YBEY and breast carcinoma.