SLC22A12 and hyperuricemia: It is documented that soluble uric acid induced the expression of GLUT9 and URAT1 in renal tubular epithelial cells of hyperuricemia mice/rats and was inhibited by FPS [16,17,18,19], which was reconfirmed by these in vitro findings, suggesting that FPS is effective in repressing reabsorption of urate from kidneys.