KRAS and cancer: In a study involving 158 patients with pathologically proven RC, who had undergone preoperative MRI, the mean values of six texture parameters (mean, variance, skewness, entropy, gray-level nonuniformity, run-length nonuniformity) were significantly higher in KRAS-mutant patients than KRAS wild-type patients having AUC values of texture features ranging from 0.703 to 0.81, and higher T stage and lower ADC values occurring in KRAS-mutant cancers [76] (Figure 7).