MAPK8 and neurodegenerative disease: An innovative therapeutic strategy for treating neurodegenerative disease is represented by the attenuation of neuroinflammation, and several in vivo studies showed that resveratrol effectively reduces the increased expression of pro-inflammatory cytokines, inhibiting NF-κB and reducing both p38-MAPK and JNK phosphorylation, decreases COX-2 and iNOS expression and inhibits microglial and astroglial activation [37,38,39].