Preservation of cardiac function and chamber size with reduced interstitial fibrosis observed in the global TREK-1 KO was phenocopied in the CF-specific TREK-1 KO mice, but not the WT or myocyte-specific TREK-1 KO mice, indicating that the cardioprotective effect of global TREK-1 deletion was due to loss of TREK-1 expression specifically in fibroblasts [234]. This evidence concerns the gene KCNK2 and cystic fibrosis.