This contrasts previous reports which demonstrated that resident mast cells enhanced the development of transplantable cutaneous tumors (e.g., B16-F10 melanoma) in c-Kit-dependent models such as B6.Cg-KitW-sh/W-sh (Wsh) and WBB6F1/J-KitW/KitW-v/J [19,33]. This evidence concerns the gene KIT and melanoma.