SQSTM1 and dry age related macular degeneration: Felszeghy et al. used Nrf2/PGC-1α double knock-out mice to study the role of autophagy in the development of dry AMD and observed high levels of oxidative stress markers, such as 4-HNE, damaged mitochondria and large autolysosomes in the RPE cells, along with an increase in p62/SQSTM1, Beclin-1 and LC3B [146].