In 2013, the Beckman Initiative for Macular Research Classification Committee proposed a new classification of AMD, in which progression of disease was defined by the size of drusen, presence of retinal pigment epithelium (RPE) changes and occurrence of choroidal neovascularization (CNV), mainly driven by the over-expression of VEGF, and/or geographic atrophy (GA) in the late stages [3]. Here, VEGFA is linked to age-related macular degeneration.