In the present study, accordingly with previous reports [45,55,57,58,59], expression of both, Nrf-2 and HO-1, was decreased in the arthritic group, by contrast, dietary OLE could restore Nrf-2 and HO-1 expressions, conferring a role for Nrf-2/HO-1 axis in the beneficial effects of dietary OLE in this murine model of RA. This evidence concerns the gene HMOX1 and rheumatoid arthritis.