In addition, based on machine learning techniques, a current research work reported that AI applications could assist in analyzing the content of specific serum protein biomarkers, including leucine-rich alpha-2-glycoprotein 1 (LRG1), epidermal growth factor receptor (EGFR), inter-alpha-trypsin inhibitor heavy-chain family member 4 (ITIH4), hemopexin (HPX) and superoxide dismutase 3 (SOD3) in order to identify CRC with 70% sensitivity at over 89% specificity (AUC = 0.86) [68]. Here, ITIH4 is linked to colorectal carcinoma.