Increasing evidence shows that non-coding RNAs (ncRNAs) contribute to every stage of colorectal tumorigenesis and cancer progression by influencing essential signaling pathways, including WNT/β-catenin, phosphoinositide-3-kinase (PI3K)/ protein kinase B (Akt), epidermal growth factor receptor (EGFR), NOTCH1, mechanistic target of rapamycin (mTOR) and TP53 [15]. The gene discussed is EGFR; the disease is cancer.