Alcocer-Gómez et al. [124] observed increased gene expression of NLRP3 and caspase-1 in blood cells, and increased serum levels of IL-1β and IL-18 in non-treated patients with adult MDD, whilst IL-1β and IL-18 correlated with the Beck Depression Inventory scores [124]. The gene discussed is CASP1; the disease is major depressive disorder.