The down-regulation of miR-664b has a potential association with the extremely significant up-regulation of interleukin 17A (IL17A) (18.584-fold change, p < 0.001) in S. aureus-inoculated quarters, which plays a crucial role in the defense of Gram-positive bacterial infection and inflammation development [45,46,47]. The gene discussed is IL17A; the disease is gram-positive bacterial infections.