Moreover, CAFs elicit structural remodeling of the extracellular matrix (ECM), by the release of protein-lysine 6-oxidase (LOX), matrix metalloproteases (MMPs) like MMP1, MMP2, MMP3, MMP9, and matricellular proteins including periostin, tenascin-C, and osteopontin, thus promoting tumor growth and local invasiveness [7]. Here, SPP1 is linked to neoplasm.