The recruitment of bone marrow-derived monocytes, which differentiate into TAMs, is driven by circulating mediators released by both tumor and stromal cells, including cytokines (IL-1β, IL-10, IL-13, IL-34), osteoactivin, VEGF-A, and colony stimulating factor-1 (CSF-1) [68,72,73]. This evidence concerns the gene IL10 and neoplasm.