Intratumoral neutrophils (TANs) are engaged into the TME through the angiogenic chemokine CXCL5, which is secreted by tumor and stroma cells via the activated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and extracellular signal-regulated kinase 1/2 (ERK1/2) pathway [80]. This evidence concerns the gene AKT1 and neoplasm.