ST3GAL4 and X-linked cone dysfunction syndrome with myopia: Another gene with hypomethylated CpG sites in individuals diagnosed with BED, and not in those diagnosed with BN, is ST3GAL4. ST3GAL4, ST3 beta-galactoside alpha-2,3-sialyltransferase 4, is one of the six enzymes that catalyzes Sia-2,3Gal linkages at the ends of glycoproteins.